Considering how much damage was done to the midwest from tornadoes this past week, everyone should have a safe place to go and be ready - for 'anything' and 'everything'. Obvously, with tornadoes, you can't keep your supplies on the first floor, but basement areas seem to be okay - storm cellars are always a good idea. May work two jobs, does without personal luxuries, hopes their children will do better than themselves.
Simultaneously, a locus segregating with a minority of early-onset familial AD kindreds was mapped to this chromosome, in the same region as the APP gene. Subsequently, several missense mutations within the APP gene that resulted in amino acid substitutions in APP were identified in these familial AD kindreds.
Such mutations appear to alter the previously described proteolytic processing of APP, generating amyloidogenic forms of Ab. Numerous missense mutations have been identified on a strong candidate gene, called PS1. At the same time, another autosomal dominant locus responsible for early-onset AD was localized to chromosome 1.
Two mutations were identified on the candidate gene, designated PS2. The physiological role of presenilins and the pathogenic effects of their mutations are not yet well understood.
The gene is inherited as an autosomal codominant trait with 3 alleles. Hypertension has been shown to interact with APOE E4 genotype to increase amyloid deposition in cognitively healthy middle-aged and older adults; controlling hypertension may significantly decrease the risk of developing amyloid deposits, even in those with genetic risk.
A collaborative study has suggested that APOE E4 exerts its maximal effect before the age of 70 years. According to one study, exposure to particulate matter PM in the ambient air and its interactions with APOE alleles may contribute to the acceleration of brain aging and the pathogenesis of AD.
None of the women had dementia when the study began. Disturbances in insulin metabolism may not cause neurological changes but may influence and accelerate these changes, leading to an earlier onset of AD.
Infection An emerging field of research suggests a significant association between AD and chronic infection with various species of spirochetes, including the periodontal pathogen Treponemas and Borrelia burgdorferi, as well as pathogens such as herpes simplex virus type 1.
Ab has been shown to be an antimicrobial peptide, so its accumulation might represent a response to infection. Depression Depression has been identified as a risk factor for AD and other dementias. Recent Framingham data have helped bolster the epidemiological association.
In another related study, recurrent depression was noted to be particularly pernicious. The analysis included data on patients 50 years and older who were free of dementia at baseline. The total sample included in the pooled analysis for all-cause dementia was 49, participants, of whom had late-life depression.
The study sample included women mean age, 46 yearsborn between andwho were followed up with in,and Data show those women who experienced the onset of depression before age 20 years were three times more likely to develop AD adjusted HR, 3.
The study also found that the presence of the APOE gene and sustaining head trauma seemed to act additively to increase the risk of developing AD, although there was no direct correlation.
Epigenetic elements in AD are suggested by facts that the majority of cases of AD are sporadic, occur in patients without a family history of the disease, and have onset late in life.
One environmental factor that has shown damage in laboratory animals consistent with human AD is lead. Early exposure to lead in monkeys resulted in plaque formation as they aged. Oxidative stress is the accumulation of excess free radicals that alter methylation patterns in the cells.
Early oxidative stress other than lead has been postulated as one cause of sporadic AD. Brain cells in AD exhibit overexpression and repression of AD genes, suggesting hypomethylation and hypermethylation, which are associated with oxidative stress. Consequently, it is possible that the use of antioxidant supplements starting in childhood might decrease long-term oxidative stress and decrease the incidence of AD.
The work of Harman indicates that antioxidants may decrease cell damage and aging by decreasing excess oxidative stress.A year ago today was the last time I heard my husband say my name coherently.
It was a year ago I sat with him and wondered how much longer I could go on. FLUORIDE COMBINES WITH ALUMINIUM IN DRINKING WATER. NEW STUDY SHOWS GRAVE IMPLICATIONS FROM INTERACTION OF ALUMINUM AND LOW DOSE FLUORIDE.
Promoters of fluoridation can no longer get away with the "unequivocal statement" that fluoride is a "free ion" in water", OR that "it completely dissociates and doesn't react with other minerals in drinking water.".
The seven stages of Alzheimer's are helpful in finding the words to discuss Alzheimer's. Caregivers find them particularly useful in support groups, as well as . Press Releases & In the News.
News on emerging health issues, new trends in medicine and research, and connect with top experts at Mount Sinai. Grain consumption appears strongly protective against Alzheimer’s disease, whereas animal fat intake has been linked to dementia risk.
Below is an approximation of this video’s audio content. To see any graphs, charts, graphics, images, and quotes to which Dr. Greger may be referring, watch the. Summary. Alzheimer’s disease (AD) can be devastating.
Research to date suggests higher blood levels of vitamin D may help prevent AD and recent animal studies indicate high-dose vitamin D supplementation may help treat the disease by reducing the abnormal proteins in the brain that are associated with the disease.